BDBM50380313 CHEMBL1234354::US8633204, 286

SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OCCO)c1=O

InChI Key InChIKey=XDLYKKIQACFMJG-WKILWMFISA-N

Data  8 KI  16 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50380313   

LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  0.570nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  0.570nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  1.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of choline acetyltransferase (ChAT) activityMore data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaMore data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate by Kinase-Glo assayMore data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate compound preincubated for 15 mins by luciferase-based luminescence assayMore data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  4.85nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate preincubated for 15 mins before substrate addition by luciferase-based luminescen...More data for this Ligand-Target Pair